Function Description ******************** Name: Z_D_MELT Function: Pierre Lavigne's dimer melt function Parameters: a0 a1 a2 a3 a4 a5 a6 a7 Notes ***** D_MELT: model to fit temperature denaturation of a dimeric protein NOTE: The temperature must be in celcius. a0= mean residue ellipticity for the N state @ 0oC a1= constant slope for the temperature dependance of the mean residue ellipticity of the N state a2= mean residue ellipticity for the N state @ 0oC a3= constant slope for the temperature dependance of the mean residue ellipticity of the N state a4= DHu (kcal/mol) a5= DCp,u (temperature independent, kcal/K mol) a6= Tm (K) a7= concentration (M) C-code for the function ********************** b = x + 273.15; c = b*((a[4] / a[6]) + a[5] * log(b/ a[6]) + 0.001987 * log(a[7])); d = a[4] + ( a[5] * (b - a[6])); e = d - c; f = exp((-e) / (b * 0.001987)); g = (-f + sqrt((f*f) + 8.0 * a[7] * f)) / (4.0 * a[7]); answer = (1.0 - g) * (a[0] - a[1] * x) + g * (a[2] - a[3] * x);