Function Description ******************** Name: Z_M_MELT Function: Pierre Lavigne's monomer melt function Parameters: a0 a1 a2 a3 a4 a5 a6 Notes ***** M_MELT: model to fit temperature denaturation of a monomeric protein monitored with circular dichroism. NOTE: The temperature must be in Celcius See Lavigne et al. 1998. J. Mol. Biol. 281, 165- a0= mean residue ellipticity for the N state @ 0oC a1= constant slope for the temperature dependance of the mean residue ellipticity of the N state a2= mean residue ellipticity for the N state @ 0oC a3= constant slope for the temperature dependance of the mean residue ellipticity of the N state a4= DHu (kcal/mol) a5= DCp,u (temperature independent, kcal/K mol) a6= Tm (K) C-code for the function *********************** b = x + 273.15; c = b *((a[4] / a[6]) + a[5] * log(b / a[6])); d = a[4] + a[5] * (b - a[6]); e = (d - c) / 0.001987; f = exp((-e) / b); g = f / (1 + f); answer = (1 - g) * (a[0] - a[1] * x) + g * (a[2] - a[3] * x);