bdswiki - User contributions [en]

Sykes NMR Wiki

2022-12-12T21:25:49Z

Nmruser:

Welcome to our lab in the
[http://www.ualberta.ca/biochemistry/index.html Department of Biochemistry]
[http://www.ualberta.ca University of Alberta].
 
 [[Image:OC.jpeg|thumb|800x800px|center| Order of Canada]]
 
 
 We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction.
 Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research.
 One recent focus has been the discovery and development of calcium sensitizers as potential drugs.
 The overlay of NMR solution structures and cryoEM structures reveal the mechanism of action of the drug W7.
 
 [[Image:W7.jpeg|thumb|800x800px|left| ACS Chemical Biology (2022)]]
 
 [[Image:TnScheme2.jpg|thumb|824x505px|left| ACS Chemical Biology 9 2121 (2014)]]
 
 
 [[Image:3mDPA.jpg]]
 
 Titration of drug into cardiac TnC-TnI chimera monitored using 1H,15- NMR correlation spectroscopy; JMCC 2016.
 
 [[Image:TOC_2018.png]]
 
Mass spect data showing thioimidate formation in Troponin; Biochemistry, 2018.
 
 [[Image:Group_2018.png|thumb|824x505px|left|Group, 2018]]
 
 [[Image:Group 2020.JPG|thumb|824x505px|left|Present Group]]

 
 [[Image:Golf2017.JPG|thumb|824x505px|left|Golf, 2017]]

 [[Image:Exit.png|thumb|824x505px|left|Recent lab trip May 2018 ]]

 [[Image:Winners_2018.JPG|thumb|824x505px|left|Winners, 2018]]

Sykes NMR Wiki

2022-12-12T21:21:52Z

Nmruser:

Welcome to our lab in the
[http://www.ualberta.ca/biochemistry/index.html Department of Biochemistry]
[http://www.ualberta.ca University of Alberta].
 
 [[Image:OC.jpeg|thumb|800x800px|left| Order of Canada]]
 
 
 We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction.
 Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research.
 One recent focus has been the discovery and development of calcium sensitizers as potential drugs.
 The overlay of NMR solution structures and cryoEM structures reveal the mechanism of action of the drug W7.
 
 [[Image:W7.jpeg|thumb|800x800px|left| ACS Chemical Biology (2022)]]
 
 [[Image:TnScheme2.jpg|thumb|824x505px|left| ACS Chemical Biology 9 2121 (2014)]]
 
 
 [[Image:3mDPA.jpg]]
 
 Titration of drug into cardiac TnC-TnI chimera monitored using 1H,15- NMR correlation spectroscopy; JMCC 2016.
 
 [[Image:TOC_2018.png]]
 
Mass spect data showing thioimidate formation in Troponin; Biochemistry, 2018.
 
 [[Image:Group_2018.png|thumb|824x505px|left|Group, 2018]]
 
 [[Image:Group 2020.JPG|thumb|824x505px|left|Present Group]]

 
 [[Image:Golf2017.JPG|thumb|824x505px|left|Golf, 2017]]

 [[Image:Exit.png|thumb|824x505px|left|Recent lab trip May 2018 ]]

 [[Image:Winners_2018.JPG|thumb|824x505px|left|Winners, 2018]]

File:OC.jpeg

2022-12-12T21:19:59Z

Nmruser:

Sykes NMR Wiki

2022-12-12T21:19:14Z

Nmruser:

Welcome to our lab in the
[http://www.ualberta.ca/biochemistry/index.html Department of Biochemistry]
[http://www.ualberta.ca University of Alberta].
 
 [[Image:OC.jpeg|thumb|800x800px|left| Order of Canada]]
 
 We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction.
 Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research.
 One recent focus has been the discovery and development of calcium sensitizers as potential drugs.
 The overlay of NMR solution structures and cryoEM structures reveal the mechanism of action of the drug W7.
 
 [[Image:W7.jpeg|thumb|800x800px|left| ACS Chemical Biology (2022)]]
 
 [[Image:TnScheme2.jpg|thumb|824x505px|left| ACS Chemical Biology 9 2121 (2014)]]
 
 
 [[Image:3mDPA.jpg]]
 
 Titration of drug into cardiac TnC-TnI chimera monitored using 1H,15- NMR correlation spectroscopy; JMCC 2016.
 
 [[Image:TOC_2018.png]]
 
Mass spect data showing thioimidate formation in Troponin; Biochemistry, 2018.
 
 [[Image:Group_2018.png|thumb|824x505px|left|Group, 2018]]
 
 [[Image:Group 2020.JPG|thumb|824x505px|left|Present Group]]

 
 [[Image:Golf2017.JPG|thumb|824x505px|left|Golf, 2017]]

 [[Image:Exit.png|thumb|824x505px|left|Recent lab trip May 2018 ]]

 [[Image:Winners_2018.JPG|thumb|824x505px|left|Winners, 2018]]

Sykes NMR Wiki

2022-05-27T16:59:35Z

Nmruser:

Sykes NMR Wiki

2022-05-18T18:54:30Z

Nmruser:

Sykes NMR Wiki

2022-05-18T18:53:10Z

Nmruser:

Sykes NMR Wiki

2022-05-18T18:52:50Z

Nmruser:

Sykes NMR Wiki

2022-05-18T18:51:40Z

Nmruser:

Sykes NMR Wiki

2022-05-18T18:50:27Z

Nmruser:

Sykes NMR Wiki

2022-05-18T18:49:30Z

Nmruser:

Sykes NMR Wiki

2022-05-18T18:48:26Z

Nmruser:

Sykes NMR Wiki

2022-05-18T18:47:25Z

Nmruser:

Sykes NMR Wiki

2022-05-18T18:46:11Z

Nmruser:

Sykes NMR Wiki

2022-05-18T18:45:07Z

Nmruser:

Sykes NMR Wiki

2022-05-18T18:44:12Z

Nmruser:

Sykes NMR Wiki

2022-05-18T18:42:19Z

Nmruser:

Sykes NMR Wiki

2022-05-18T18:40:18Z

Nmruser:

Sykes NMR Wiki

2022-05-18T18:39:33Z

Nmruser:

File:W7.jpeg

2022-05-18T18:38:56Z

Nmruser:

Sykes NMR Wiki

2022-05-18T18:37:28Z

Nmruser:

File:Fig7 new copy.pdf

2022-05-18T18:34:02Z

Nmruser:

Sykes NMR Wiki

2021-08-19T20:50:39Z

Nmruser:

File:TnScheme2.jpg

2021-08-19T20:50:23Z

Nmruser:

File:TnScheme.jpg

2021-08-19T20:47:14Z

Nmruser: Nmruser uploaded a new version of "File:TnScheme.jpg"

File:TnScheme.jpg

2021-08-19T20:43:28Z

Nmruser: Nmruser uploaded a new version of "File:TnScheme.jpg": Reverted to version as of 20:40, 19 August 2021

File:TnScheme.jpg

2021-08-19T20:42:54Z

Nmruser: Nmruser uploaded a new version of "File:TnScheme.jpg": Reverted to version as of 20:17, 19 August 2021

File:TnScheme.jpg

2021-08-19T20:40:50Z

Nmruser: Nmruser uploaded a new version of "File:TnScheme.jpg"

File:TnScheme.jpg

2021-08-19T20:17:33Z

Nmruser: Nmruser uploaded a new version of "File:TnScheme.jpg"

Sykes NMR Wiki

2021-01-28T21:47:06Z

Nmruser:

File:Winners 2018.JPG

2021-01-28T21:45:56Z

Nmruser:

Sykes NMR Wiki

2021-01-28T21:43:20Z

Nmruser:

File:Group 2020.JPG

2021-01-28T21:39:25Z

Nmruser:

Sykes NMR Wiki

2020-10-29T20:55:08Z

Nmruser:

Welcome to our lab in the
[http://www.ualberta.ca/biochemistry/index.html Department of Biochemistry]
[http://www.ualberta.ca University of Alberta].
 We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction.
 Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research.
 One recent focus has been the discovery and development of calcium sensitizers as potential drugs.
 The following figure captures many of the intrinsically disordered regions of the Troponin protein complex involved in the regulation of cardiac muscle contraction.
 [[Image:TnScheme.jpg|thumb|824x505px|left| ACS Chemical Biology 9 2121 (2014)]]
 
 [[Image:3mDPA.jpg]]
 
Titration of drug into cardiac TnC-TnI chimera monitored using 1H,15- NMR correlation spectroscopy; JMCC 2016.
 
 [[Image:TOC_2018.png]]
 
Mass spect data showing thioimidate formation in Troponin; Biochemistry, 2018.
 
 [[Image:Group_2018.png|thumb|824x505px|left|Present group, 2018]]

 
 [[Image:Golf2017.JPG|thumb|824x505px|left|Golf, 2017]]

 [[Image:Exit.png|thumb|824x505px|left|Recent lab trip May 2018 ]]

 

{|border="5" | style="text-align: left;"
|-
! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Sykes%20BD%22&dispmax=50 Publications] || PubMed (Sykes BD)
|-
! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Bleackley%20RC%22OR%22Brindley%20DN%22OR%22Ellison%20MJ%22OR%22Fliegel%20L%22OR%22Glover%20JN%22OR%22Holmes%20CF%22OR%22James%20MN%22OR%22Lemire%20BD%22OR%22MacMillan%20AM%22OR%22McElhaney%20RN%22OR%22Michalak%20M%22OR%22Schultz%20MC%22OR%22Stone%20JC%22OR%22Sykes%20BD%22OR%22Vance%20DE%22OR%22Weiner%20JH%22OR%22Fernandez-Patron%20C%22OR%22Schang%20LM%22OR%22Spyracopoulos%20L%22OR%22Stuart%20DT%22OR%22Young%20HS%22OR%22Fahlman%20RP%22OR%22Goping%20IS%22OR%22Lemieux%20MJ%22OR%22Touret%20N%22OR%22Wille%20H%22OR%22Casey%20JR%22AND%22last%2012%20months%22%5Bdp%5D&dispmax=50 Dept of Biochem] || last 12 months
|-
! [http://www.rcsb.org/ PDB] || Protein Data Bank
|-
! [http://www.nanuc.ca/ NANUC] || National NMR Centre
|-
! [https://agilent-ext.hosted.jivesoftware.com/login.jspa?logout/ SpinSights] || Agilent NMR
|-
! [http://www.ehs.ualberta.ca/DocumentsandProcedures/~/media/Environmental%20Health%20and%20Safety/Documents/Biosafety/Biosafety_Guidelines.pdf Biosafety] || Biosafety Guidelines
|-
! [http://www.ehs.ualberta.ca/DocumentsandProcedures/~/media/Environmental%20Health%20and%20Safety/Documents/Manuals%20and%20Documents/Lab_Chemical_Safety_Manual.ashx Chemsafety] || Chem Safety Manual
|-
|}
 

== Recent News ==

{|border="5" | style="text-align: left;"
|-
|*Sept 2017 New edits

|-
|}

Sykes NMR Wiki

2018-05-28T18:00:23Z

Nmruser:

Welcome to our lab in the
[http://www.ualberta.ca/medicine/departments/biochemistry Department of Biochemistry]
[http://www.ualberta.ca University of Alberta].
 We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction.
 Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research.
 One recent focus has been the discovery and development of calcium sensitizers as potential drugs.
 The following figure captures many of the intrinsically disordered regions of the Troponin protein complex involved in the regulation of cardiac muscle contraction.
 [[Image:TnScheme.jpg|thumb|824x505px|left| ACS Chemical Biology 9 2121 (2014)]]
 
 [[Image:3mDPA.jpg]]
 
Titration of drug into cardiac TnC-TnI chimera monitored using 1H,15- NMR correlation spectroscopy; JMCC 2016.
 
 [[Image:TOC_2018.png]]
 
Mass spect data showing thioimidate formation in Troponin; Biochemistry, 2018.
 
 [[Image:Group_2018.png|thumb|824x505px|left|Present group, 2018]]

 
 [[Image:Golf2017.JPG|thumb|824x505px|left|Golf, 2017]]

 [[Image:Exit.png|thumb|824x505px|left|Recent lab trip May 2018 ]]

 

{|border="5" | style="text-align: left;"
|-
! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Sykes%20BD%22&dispmax=50 Publications] || PubMed (Sykes BD)
|-
! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Bleackley%20RC%22OR%22Brindley%20DN%22OR%22Ellison%20MJ%22OR%22Fliegel%20L%22OR%22Glover%20JN%22OR%22Holmes%20CF%22OR%22James%20MN%22OR%22Lemire%20BD%22OR%22MacMillan%20AM%22OR%22McElhaney%20RN%22OR%22Michalak%20M%22OR%22Schultz%20MC%22OR%22Stone%20JC%22OR%22Sykes%20BD%22OR%22Vance%20DE%22OR%22Weiner%20JH%22OR%22Fernandez-Patron%20C%22OR%22Schang%20LM%22OR%22Spyracopoulos%20L%22OR%22Stuart%20DT%22OR%22Young%20HS%22OR%22Fahlman%20RP%22OR%22Goping%20IS%22OR%22Lemieux%20MJ%22OR%22Touret%20N%22OR%22Wille%20H%22OR%22Casey%20JR%22AND%22last%2012%20months%22%5Bdp%5D&dispmax=50 Dept of Biochem] || last 12 months
|-
! [http://www.rcsb.org/ PDB] || Protein Data Bank
|-
! [http://www.nanuc.ca/ NANUC] || National NMR Centre
|-
! [https://agilent-ext.hosted.jivesoftware.com/login.jspa?logout/ SpinSights] || Agilent NMR
|-
! [http://www.ehs.ualberta.ca/DocumentsandProcedures/~/media/Environmental%20Health%20and%20Safety/Documents/Biosafety/Biosafety_Guidelines.pdf Biosafety] || Biosafety Guidelines
|-
! [http://www.ehs.ualberta.ca/DocumentsandProcedures/~/media/Environmental%20Health%20and%20Safety/Documents/Manuals%20and%20Documents/Lab_Chemical_Safety_Manual.ashx Chemsafety] || Chem Safety Manual
|-
|}
 

== Recent News ==

{|border="5" | style="text-align: left;"
|-
|*Sept 2017 New edits

|-
|}

File:Exit.png

2018-05-28T17:58:20Z

Nmruser:

Sykes NMR Wiki

2018-04-20T22:28:39Z

Nmruser:

Welcome to our lab in the
[http://www.ualberta.ca/medicine/departments/biochemistry Department of Biochemistry]
[http://www.ualberta.ca University of Alberta].
 We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction.
 Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research.
 One recent focus has been the discovery and development of calcium sensitizers as potential drugs.
 The following figure captures many of the intrinsically disordered regions of the Troponin protein complex involved in the regulation of cardiac muscle contraction.
 [[Image:TnScheme.jpg|thumb|824x505px|left| ACS Chemical Biology 9 2121 (2014)]]
 
 [[Image:3mDPA.jpg]]
 
Titration of drug into cardiac TnC-TnI chimera monitored using 1H,15- NMR correlation spectroscopy; JMCC 2016.
 
 [[Image:TOC_2018.png]]
 
Mass spect data showing thioimidate formation in Troponin; Biochemistry, 2018.
 
 [[Image:Group_2018.png|thumb|824x505px|left|Present group, 2018]]

 
 [[Image:Golf2017.JPG|thumb|824x505px|left|Golf, 2017]]

 [[Image:Sandy_2016.jpg|thumb|824x505px|left|Recent lab visit, April 2016 (see [[Personnel]] and [[Pictures of the group]]) ]]

 

{|border="5" | style="text-align: left;"
|-
! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Sykes%20BD%22&dispmax=50 Publications] || PubMed (Sykes BD)
|-
! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Bleackley%20RC%22OR%22Brindley%20DN%22OR%22Ellison%20MJ%22OR%22Fliegel%20L%22OR%22Glover%20JN%22OR%22Holmes%20CF%22OR%22James%20MN%22OR%22Lemire%20BD%22OR%22MacMillan%20AM%22OR%22McElhaney%20RN%22OR%22Michalak%20M%22OR%22Schultz%20MC%22OR%22Stone%20JC%22OR%22Sykes%20BD%22OR%22Vance%20DE%22OR%22Weiner%20JH%22OR%22Fernandez-Patron%20C%22OR%22Schang%20LM%22OR%22Spyracopoulos%20L%22OR%22Stuart%20DT%22OR%22Young%20HS%22OR%22Fahlman%20RP%22OR%22Goping%20IS%22OR%22Lemieux%20MJ%22OR%22Touret%20N%22OR%22Wille%20H%22OR%22Casey%20JR%22AND%22last%2012%20months%22%5Bdp%5D&dispmax=50 Dept of Biochem] || last 12 months
|-
! [http://www.rcsb.org/ PDB] || Protein Data Bank
|-
! [http://www.nanuc.ca/ NANUC] || National NMR Centre
|-
! [https://agilent-ext.hosted.jivesoftware.com/login.jspa?logout/ SpinSights] || Agilent NMR
|-
! [http://www.ehs.ualberta.ca/DocumentsandProcedures/~/media/Environmental%20Health%20and%20Safety/Documents/Biosafety/Biosafety_Guidelines.pdf Biosafety] || Biosafety Guidelines
|-
! [http://www.ehs.ualberta.ca/DocumentsandProcedures/~/media/Environmental%20Health%20and%20Safety/Documents/Manuals%20and%20Documents/Lab_Chemical_Safety_Manual.ashx Chemsafety] || Chem Safety Manual
|-
|}
 

== Recent News ==

{|border="5" | style="text-align: left;"
|-
|*Sept 2017 New edits

|-
|}

Sykes NMR Wiki

2018-04-20T22:28:08Z

Nmruser:

Welcome to our lab in the
[http://www.ualberta.ca/medicine/departments/biochemistry Department of Biochemistry]
[http://www.ualberta.ca University of Alberta].
 We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction.
 Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research.
 One recent focus has been the discovery and development of calcium sensitizers as potential drugs.
 The following figure captures many of the intrinsically disordered regions of the Troponin protein complex involved in the regulation of cardiac muscle contraction.
 [[Image:TnScheme.jpg|thumb|824x505px|left| ACS Chemical Biology 9 2121 (2014)]]
 
 [[Image:3mDPA.jpg]]
 
Titration of drug into cardiac TnC-TnI chimera monitored using 1H,15- NMR correlation spectroscopy.
 
 [[Image:TOC_2018.png]]
 
Mass spect data showing thioimidate formation in Troponin; Biochemistry, 2018.
 
 [[Image:Group_2018.png|thumb|824x505px|left|Present group, 2018]]

 
 [[Image:Golf2017.JPG|thumb|824x505px|left|Golf, 2017]]

 [[Image:Sandy_2016.jpg|thumb|824x505px|left|Recent lab visit, April 2016 (see [[Personnel]] and [[Pictures of the group]]) ]]

 

{|border="5" | style="text-align: left;"
|-
! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Sykes%20BD%22&dispmax=50 Publications] || PubMed (Sykes BD)
|-
! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Bleackley%20RC%22OR%22Brindley%20DN%22OR%22Ellison%20MJ%22OR%22Fliegel%20L%22OR%22Glover%20JN%22OR%22Holmes%20CF%22OR%22James%20MN%22OR%22Lemire%20BD%22OR%22MacMillan%20AM%22OR%22McElhaney%20RN%22OR%22Michalak%20M%22OR%22Schultz%20MC%22OR%22Stone%20JC%22OR%22Sykes%20BD%22OR%22Vance%20DE%22OR%22Weiner%20JH%22OR%22Fernandez-Patron%20C%22OR%22Schang%20LM%22OR%22Spyracopoulos%20L%22OR%22Stuart%20DT%22OR%22Young%20HS%22OR%22Fahlman%20RP%22OR%22Goping%20IS%22OR%22Lemieux%20MJ%22OR%22Touret%20N%22OR%22Wille%20H%22OR%22Casey%20JR%22AND%22last%2012%20months%22%5Bdp%5D&dispmax=50 Dept of Biochem] || last 12 months
|-
! [http://www.rcsb.org/ PDB] || Protein Data Bank
|-
! [http://www.nanuc.ca/ NANUC] || National NMR Centre
|-
! [https://agilent-ext.hosted.jivesoftware.com/login.jspa?logout/ SpinSights] || Agilent NMR
|-
! [http://www.ehs.ualberta.ca/DocumentsandProcedures/~/media/Environmental%20Health%20and%20Safety/Documents/Biosafety/Biosafety_Guidelines.pdf Biosafety] || Biosafety Guidelines
|-
! [http://www.ehs.ualberta.ca/DocumentsandProcedures/~/media/Environmental%20Health%20and%20Safety/Documents/Manuals%20and%20Documents/Lab_Chemical_Safety_Manual.ashx Chemsafety] || Chem Safety Manual
|-
|}
 

== Recent News ==

{|border="5" | style="text-align: left;"
|-
|*Sept 2017 New edits

|-
|}

File:3mDPA.jpg

2018-04-20T22:26:14Z

Nmruser: Nmruser uploaded a new version of "File:3mDPA.jpg": Reverted to version as of 22:17, 20 April 2018

File:3mDPA.jpg

2018-04-20T22:21:23Z

Nmruser: Nmruser uploaded a new version of "File:3mDPA.jpg"

File:3mDPA.jpg

2018-04-20T22:17:39Z

Nmruser:

Sykes NMR Wiki

2018-04-11T21:22:50Z

Nmruser:

Welcome to our lab in the
[http://www.ualberta.ca/medicine/departments/biochemistry Department of Biochemistry]
[http://www.ualberta.ca University of Alberta].
 We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction.
 Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research.
 One recent focus has been the discovery and development of calcium sensitizers as potential drugs.
 The following figure captures many of the intrinsically disordered regions of the Troponin protein complex involved in the regulation of cardiac muscle contraction.
 [[Image:TnScheme.jpg|thumb|824x505px|left| ACS Chemical Biology 9 2121 (2014)]]
 
 [[Image:Dfbp-o.png]]
 
The structure of a calcium sensitizing compound bound to the Troponin-C Troponin-I complex which regulates muscle contraction.
 
 [[Image:TOC_2018.png]]
 
Mass spect data showing thioimidate formation in Troponin; Biochemistry, 2018.
 
 [[Image:Group_2018.png|thumb|824x505px|left|Present group, 2018]]

 
 [[Image:Golf2017.JPG|thumb|824x505px|left|Golf, 2017]]

 [[Image:Sandy_2016.jpg|thumb|824x505px|left|Recent lab visit, April 2016 (see [[Personnel]] and [[Pictures of the group]]) ]]

 

{|border="5" | style="text-align: left;"
|-
! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Sykes%20BD%22&dispmax=50 Publications] || PubMed (Sykes BD)
|-
! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Bleackley%20RC%22OR%22Brindley%20DN%22OR%22Ellison%20MJ%22OR%22Fliegel%20L%22OR%22Glover%20JN%22OR%22Holmes%20CF%22OR%22James%20MN%22OR%22Lemire%20BD%22OR%22MacMillan%20AM%22OR%22McElhaney%20RN%22OR%22Michalak%20M%22OR%22Schultz%20MC%22OR%22Stone%20JC%22OR%22Sykes%20BD%22OR%22Vance%20DE%22OR%22Weiner%20JH%22OR%22Fernandez-Patron%20C%22OR%22Schang%20LM%22OR%22Spyracopoulos%20L%22OR%22Stuart%20DT%22OR%22Young%20HS%22OR%22Fahlman%20RP%22OR%22Goping%20IS%22OR%22Lemieux%20MJ%22OR%22Touret%20N%22OR%22Wille%20H%22OR%22Casey%20JR%22AND%22last%2012%20months%22%5Bdp%5D&dispmax=50 Dept of Biochem] || last 12 months
|-
! [http://www.rcsb.org/ PDB] || Protein Data Bank
|-
! [http://www.nanuc.ca/ NANUC] || National NMR Centre
|-
! [https://agilent-ext.hosted.jivesoftware.com/login.jspa?logout/ SpinSights] || Agilent NMR
|-
! [http://www.ehs.ualberta.ca/DocumentsandProcedures/~/media/Environmental%20Health%20and%20Safety/Documents/Biosafety/Biosafety_Guidelines.pdf Biosafety] || Biosafety Guidelines
|-
! [http://www.ehs.ualberta.ca/DocumentsandProcedures/~/media/Environmental%20Health%20and%20Safety/Documents/Manuals%20and%20Documents/Lab_Chemical_Safety_Manual.ashx Chemsafety] || Chem Safety Manual
|-
|}
 

== Recent News ==

{|border="5" | style="text-align: left;"
|-
|*Sept 2017 New edits

|-
|}

Sykes NMR Wiki

2018-04-10T21:59:46Z

Nmruser:

Welcome to our lab in the
[http://www.ualberta.ca/medicine/departments/biochemistry Department of Biochemistry]
[http://www.ualberta.ca University of Alberta].
 We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction.
 Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research.
 One recent focus has been the discovery and development of calcium sensitizers as potential drugs.
 The following figure captures many of the intrinsically disordered regions of the Troponin protein complex involved in the regulation of cardiac muscle contraction.
 [[Image:TnScheme.jpg|thumb|824x505px|left| ACS Chemical Biology 9 2121 (2014)]]
 
 [[Image:Dfbp-o.png]]
 
The structure of a calcium sensitizing compound bound to the Troponin-C Troponin-I complex which regulates muscle contraction.
 
 [[Image:TOC_2018.png]]
 
Mass spect data showing thioimidate formation in Troponin.
 
 [[Image:Group_2018.png|thumb|824x505px|left|Present group, 2018]]

 
 [[Image:Golf2017.JPG|thumb|824x505px|left|Golf, 2017]]

 [[Image:Sandy_2016.jpg|thumb|824x505px|left|Recent lab visit, April 2016 (see [[Personnel]] and [[Pictures of the group]]) ]]

 

{|border="5" | style="text-align: left;"
|-
! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Sykes%20BD%22&dispmax=50 Publications] || PubMed (Sykes BD)
|-
! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Bleackley%20RC%22OR%22Brindley%20DN%22OR%22Ellison%20MJ%22OR%22Fliegel%20L%22OR%22Glover%20JN%22OR%22Holmes%20CF%22OR%22James%20MN%22OR%22Lemire%20BD%22OR%22MacMillan%20AM%22OR%22McElhaney%20RN%22OR%22Michalak%20M%22OR%22Schultz%20MC%22OR%22Stone%20JC%22OR%22Sykes%20BD%22OR%22Vance%20DE%22OR%22Weiner%20JH%22OR%22Fernandez-Patron%20C%22OR%22Schang%20LM%22OR%22Spyracopoulos%20L%22OR%22Stuart%20DT%22OR%22Young%20HS%22OR%22Fahlman%20RP%22OR%22Goping%20IS%22OR%22Lemieux%20MJ%22OR%22Touret%20N%22OR%22Wille%20H%22OR%22Casey%20JR%22AND%22last%2012%20months%22%5Bdp%5D&dispmax=50 Dept of Biochem] || last 12 months
|-
! [http://www.rcsb.org/ PDB] || Protein Data Bank
|-
! [http://www.nanuc.ca/ NANUC] || National NMR Centre
|-
! [https://agilent-ext.hosted.jivesoftware.com/login.jspa?logout/ SpinSights] || Agilent NMR
|-
! [http://www.ehs.ualberta.ca/DocumentsandProcedures/~/media/Environmental%20Health%20and%20Safety/Documents/Biosafety/Biosafety_Guidelines.pdf Biosafety] || Biosafety Guidelines
|-
! [http://www.ehs.ualberta.ca/DocumentsandProcedures/~/media/Environmental%20Health%20and%20Safety/Documents/Manuals%20and%20Documents/Lab_Chemical_Safety_Manual.ashx Chemsafety] || Chem Safety Manual
|-
|}
 

== Recent News ==

{|border="5" | style="text-align: left;"
|-
|*Sept 2017 New edits

|-
|}

File:TOC 2018.png

2018-04-10T21:56:12Z

Nmruser:

File:TOC 2018.pdf

2018-04-10T21:52:50Z

Nmruser:

Sykes NMR Wiki

2018-04-09T22:31:32Z

Nmruser:

Welcome to our lab in the
[http://www.ualberta.ca/medicine/departments/biochemistry Department of Biochemistry]
[http://www.ualberta.ca University of Alberta].
 We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction.
 Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research.
 One recent focus has been the discovery and development of calcium sensitizers as potential drugs.
 The following figure captures many of the intrinsically disordered regions of the Troponin protein complex involved in the regulation of cardiac muscle contraction.
 [[Image:TnScheme.jpg|thumb|824x505px|left| ACS Chemical Biology 9 2121 (2014)]]
 
 [[Image:Dfbp-o.png]]
 
The structure of a calcium sensitizing compound bound to the Troponin-C Troponin-I complex which regulates muscle contraction.
 

 [[Image:Group_2018.png|thumb|824x505px|left|Present group, 2018]]

 
 [[Image:Golf2017.JPG|thumb|824x505px|left|Golf, 2017]]

 [[Image:Sandy_2016.jpg|thumb|824x505px|left|Recent lab visit, April 2016 (see [[Personnel]] and [[Pictures of the group]]) ]]

 

{|border="5" | style="text-align: left;"
|-
! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Sykes%20BD%22&dispmax=50 Publications] || PubMed (Sykes BD)
|-
! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Bleackley%20RC%22OR%22Brindley%20DN%22OR%22Ellison%20MJ%22OR%22Fliegel%20L%22OR%22Glover%20JN%22OR%22Holmes%20CF%22OR%22James%20MN%22OR%22Lemire%20BD%22OR%22MacMillan%20AM%22OR%22McElhaney%20RN%22OR%22Michalak%20M%22OR%22Schultz%20MC%22OR%22Stone%20JC%22OR%22Sykes%20BD%22OR%22Vance%20DE%22OR%22Weiner%20JH%22OR%22Fernandez-Patron%20C%22OR%22Schang%20LM%22OR%22Spyracopoulos%20L%22OR%22Stuart%20DT%22OR%22Young%20HS%22OR%22Fahlman%20RP%22OR%22Goping%20IS%22OR%22Lemieux%20MJ%22OR%22Touret%20N%22OR%22Wille%20H%22OR%22Casey%20JR%22AND%22last%2012%20months%22%5Bdp%5D&dispmax=50 Dept of Biochem] || last 12 months
|-
! [http://www.rcsb.org/ PDB] || Protein Data Bank
|-
! [http://www.nanuc.ca/ NANUC] || National NMR Centre
|-
! [https://agilent-ext.hosted.jivesoftware.com/login.jspa?logout/ SpinSights] || Agilent NMR
|-
! [http://www.ehs.ualberta.ca/DocumentsandProcedures/~/media/Environmental%20Health%20and%20Safety/Documents/Biosafety/Biosafety_Guidelines.pdf Biosafety] || Biosafety Guidelines
|-
! [http://www.ehs.ualberta.ca/DocumentsandProcedures/~/media/Environmental%20Health%20and%20Safety/Documents/Manuals%20and%20Documents/Lab_Chemical_Safety_Manual.ashx Chemsafety] || Chem Safety Manual
|-
|}
 

== Recent News ==

{|border="5" | style="text-align: left;"
|-
|*Sept 2017 New edits

|-
|}

Sykes NMR Wiki

2018-04-09T22:30:40Z

Nmruser:

Welcome to our lab in the
[http://www.ualberta.ca/medicine/departments/biochemistry Department of Biochemistry]
[http://www.ualberta.ca University of Alberta].
 We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction.
 Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research.
 One recent focus has been the discovery and development of calcium sensitizers as potential drugs.
 The following figure captures many of the intrinsically disordered regions of the Troponin protein complex involved in the regulation of cardiac muscle contraction.
 [[Image:TnScheme.jpg|thumb|824x505px|left| ACS Chemical Biology 9 2121 (2014)]]
 
 [[Image:Dfbp-o.png]]
 
The structure of a calcium sensitizing compound bound to the Troponin-C Troponin-I complex which regulates muscle contraction.
 

 [[Image:Group_2018.png|thumb|824x505px|left|Present group, 2018]]
[[Image:BAK.jpeg|thumb|824x505px|right|Brittney]]
 
 [[Image:Golf2017.JPG|thumb|824x505px|left|Golf, 2017]]

 [[Image:Sandy_2016.jpg|thumb|824x505px|left|Recent lab visit, April 2016 (see [[Personnel]] and [[Pictures of the group]]) ]]

 

{|border="5" | style="text-align: left;"
|-
! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Sykes%20BD%22&dispmax=50 Publications] || PubMed (Sykes BD)
|-
! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Bleackley%20RC%22OR%22Brindley%20DN%22OR%22Ellison%20MJ%22OR%22Fliegel%20L%22OR%22Glover%20JN%22OR%22Holmes%20CF%22OR%22James%20MN%22OR%22Lemire%20BD%22OR%22MacMillan%20AM%22OR%22McElhaney%20RN%22OR%22Michalak%20M%22OR%22Schultz%20MC%22OR%22Stone%20JC%22OR%22Sykes%20BD%22OR%22Vance%20DE%22OR%22Weiner%20JH%22OR%22Fernandez-Patron%20C%22OR%22Schang%20LM%22OR%22Spyracopoulos%20L%22OR%22Stuart%20DT%22OR%22Young%20HS%22OR%22Fahlman%20RP%22OR%22Goping%20IS%22OR%22Lemieux%20MJ%22OR%22Touret%20N%22OR%22Wille%20H%22OR%22Casey%20JR%22AND%22last%2012%20months%22%5Bdp%5D&dispmax=50 Dept of Biochem] || last 12 months
|-
! [http://www.rcsb.org/ PDB] || Protein Data Bank
|-
! [http://www.nanuc.ca/ NANUC] || National NMR Centre
|-
! [https://agilent-ext.hosted.jivesoftware.com/login.jspa?logout/ SpinSights] || Agilent NMR
|-
! [http://www.ehs.ualberta.ca/DocumentsandProcedures/~/media/Environmental%20Health%20and%20Safety/Documents/Biosafety/Biosafety_Guidelines.pdf Biosafety] || Biosafety Guidelines
|-
! [http://www.ehs.ualberta.ca/DocumentsandProcedures/~/media/Environmental%20Health%20and%20Safety/Documents/Manuals%20and%20Documents/Lab_Chemical_Safety_Manual.ashx Chemsafety] || Chem Safety Manual
|-
|}
 

== Recent News ==

{|border="5" | style="text-align: left;"
|-
|*Sept 2017 New edits

|-
|}

Pictures of the group

2018-04-09T22:29:04Z

Nmruser:

File:Group 2018.png

2018-04-09T22:27:41Z

Nmruser: Nmruser uploaded a new version of "File:Group 2018.png"

File:Group 2018.png

2018-04-09T22:22:50Z

Nmruser:

Sykes NMR Wiki

2017-09-22T20:47:45Z

Nmruser:

Welcome to our lab in the
[http://www.ualberta.ca/medicine/departments/biochemistry Department of Biochemistry]
[http://www.ualberta.ca University of Alberta].
 We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction.
 Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research.
 One recent focus has been the discovery and development of calcium sensitizers as potential drugs.
 The following figure captures many of the intrinsically disordered regions of the Troponin protein complex involved in the regulation of cardiac muscle contraction.
 [[Image:TnScheme.jpg|thumb|824x505px|left| ACS Chemical Biology 9 2121 (2014)]]
 
 [[Image:Dfbp-o.png]]
 
The structure of a calcium sensitizing compound bound to the Troponin-C Troponin-I complex which regulates muscle contraction.
 

 [[Image:Group 2017.jpg|thumb|824x505px|left|Present group, 2017]]
[[Image:BAK.jpeg|thumb|824x505px|right|Brittney]]
 
 [[Image:Golf2017.JPG|thumb|824x505px|left|Golf, 2017]]

 [[Image:Sandy_2016.jpg|thumb|824x505px|left|Recent lab visit, April 2016 (see [[Personnel]] and [[Pictures of the group]]) ]]

 

{|border="5" | style="text-align: left;"
|-
! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Sykes%20BD%22&dispmax=50 Publications] || PubMed (Sykes BD)
|-
! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Bleackley%20RC%22OR%22Brindley%20DN%22OR%22Ellison%20MJ%22OR%22Fliegel%20L%22OR%22Glover%20JN%22OR%22Holmes%20CF%22OR%22James%20MN%22OR%22Lemire%20BD%22OR%22MacMillan%20AM%22OR%22McElhaney%20RN%22OR%22Michalak%20M%22OR%22Schultz%20MC%22OR%22Stone%20JC%22OR%22Sykes%20BD%22OR%22Vance%20DE%22OR%22Weiner%20JH%22OR%22Fernandez-Patron%20C%22OR%22Schang%20LM%22OR%22Spyracopoulos%20L%22OR%22Stuart%20DT%22OR%22Young%20HS%22OR%22Fahlman%20RP%22OR%22Goping%20IS%22OR%22Lemieux%20MJ%22OR%22Touret%20N%22OR%22Wille%20H%22OR%22Casey%20JR%22AND%22last%2012%20months%22%5Bdp%5D&dispmax=50 Dept of Biochem] || last 12 months
|-
! [http://www.rcsb.org/ PDB] || Protein Data Bank
|-
! [http://www.nanuc.ca/ NANUC] || National NMR Centre
|-
! [https://agilent-ext.hosted.jivesoftware.com/login.jspa?logout/ SpinSights] || Agilent NMR
|-
! [http://www.ehs.ualberta.ca/DocumentsandProcedures/~/media/Environmental%20Health%20and%20Safety/Documents/Biosafety/Biosafety_Guidelines.pdf Biosafety] || Biosafety Guidelines
|-
! [http://www.ehs.ualberta.ca/DocumentsandProcedures/~/media/Environmental%20Health%20and%20Safety/Documents/Manuals%20and%20Documents/Lab_Chemical_Safety_Manual.ashx Chemsafety] || Chem Safety Manual
|-
|}
 

== Recent News ==

{|border="5" | style="text-align: left;"
|-
|*Sept 2017 New edits

|-
|}