bdswiki http://www.bionmr.ualberta.ca/bdswiki/index.php/Sykes_NMR_Wiki MediaWiki 1.20.2 first-letter Media Special Talk User User talk Bdswiki Bdswiki talk File File talk MediaWiki MediaWiki talk Template Template talk Help Help talk Category Category talk 0 1 248 247 2022-12-12T21:25:49Z Nmruser 2 t18cwuzyxmqr5h8x2qrok8btedmfmem Welcome to our lab in the [http://www.ualberta.ca/biochemistry/index.html Department of Biochemistry] [http://www.ualberta.ca University of Alberta]. <BR> <BR> [[Image:OC.jpeg|thumb|800x800px|center| Order of Canada]] <BR> <BR> <BR> We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction. <BR> Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research. <BR> One recent focus has been the discovery and development of calcium sensitizers as potential drugs. <BR> The overlay of NMR solution structures and cryoEM structures reveal the mechanism of action of the drug W7. <BR> <BR> [[Image:W7.jpeg|thumb|800x800px|left| ACS Chemical Biology (2022)]] <BR> <BR> [[Image:TnScheme2.jpg|thumb|824x505px|left| ACS Chemical Biology 9 2121 (2014)]] <BR> <BR> <BR> [[Image:3mDPA.jpg]] <BR> <BR> Titration of drug into cardiac TnC-TnI chimera monitored using 1H,15- NMR correlation spectroscopy; JMCC 2016. <BR> <BR> [[Image:TOC_2018.png]] <BR> Mass spect data showing thioimidate formation in Troponin; Biochemistry, 2018. <BR> <BR>[[Image:Group_2018.png|thumb|824x505px|left|Group, 2018]] <BR> <BR>[[Image:Group 2020.JPG|thumb|824x505px|left|Present Group]] <BR> <BR>[[Image:Golf2017.JPG|thumb|824x505px|left|Golf, 2017]] <BR>[[Image:Exit.png|thumb|824x505px|left|Recent lab trip May 2018 ]] <BR>[[Image:Winners_2018.JPG|thumb|824x505px|left|Winners, 2018]] <BR> <BR>