Sykes NMR Wiki

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Welcome to our lab in the Department of Biochemistry in the Faculty of Medicine at the University of Alberta.
We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction.
Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research.
One recent focus has been the discovery and development of calcium sensitizers as potential drugs.
The following figure captures many of the intrinsically disordered regions of the Troponin protein complex involved in the regulation of cardiac muscle contraction.


ACS Chemical Biology 9 2121 (2014)



Dfbp-o.png
The structure of a calcium sensitizing compound bound to the Troponin-C Troponin-I complex which regulates muscle contraction.


Brian Sykes' group, April 2016 (see Personnel and Pictures of the group)

Links

Publications PubMed (Sykes BD)
Dept of Biochem last 12 months
PDB Protein Data Bank
NANUC National NMR Centre
SpinSights Agilent NMR
Biosafety Biosafety Guidelines
Chemsafety Chem Safety Manual


Recent News

*April/14 New group pic *August/13 Updated group picture


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