Sykes NMR Wiki

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Welcome to our lab in the Department of Biochemistry University of Alberta.
We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction.
Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research.
One recent focus has been the discovery and development of calcium sensitizers as potential drugs.
The following figure captures many of the intrinsically disordered regions of the Troponin protein complex involved in the regulation of cardiac muscle contraction.


ACS Chemical Biology 9 2121 (2014)



3mDPA.jpg
Titration of drug into cardiac TnC-TnI chimera monitored using 1H,15- NMR correlation spectroscopy.

TOC 2018.png
Mass spect data showing thioimidate formation in Troponin; Biochemistry, 2018.


Present group, 2018



Golf, 2017

Recent lab visit, April 2016 (see Personnel and Pictures of the group)



Publications PubMed (Sykes BD)
Dept of Biochem last 12 months
PDB Protein Data Bank
NANUC National NMR Centre
SpinSights Agilent NMR
Biosafety Biosafety Guidelines
Chemsafety Chem Safety Manual


Recent News

*Sept 2017 New edits


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