Sykes NMR Wiki
Welcome to our lab in the
Department of Biochemistry
University of Alberta.
We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction.
Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research.
One recent focus has been the discovery and development of calcium sensitizers as potential drugs.
The overlay of NMR solution structures and cryoEM structures reveal the mechanism of action of the drug W7.