Sykes NMR Wiki
Welcome to our lab in the Department of Biochemistry
in the Faculty of Medicine at the
University of Alberta.
We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction.
Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research.
One recent focus has been the discovery and development of calcium sensitizers as potential drugs.
The following figure captures many of the intrinsically disordered regions of the Troponin protein complex involved in the regulation of cardiac muscle contraction.
The structure of a calcium sensitizing compound bound to the Troponin-C Troponin-I complex which regulates muscle contraction.
Publications | PubMed (Sykes BD) |
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Dept of Biochem | last 12 months |
PDB | Protein Data Bank |
NANUC | National NMR Centre |
SpinSights | Agilent NMR |
Biosafety | Biosafety Guidelines |
Chemsafety | Chem Safety Manual |
Recent News
*Sept 2017 New edits |