Difference between revisions of "Sykes NMR Wiki"
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<BR> Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research. | <BR> Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research. | ||
<BR>One recent focus has been the discovery and development of calcium sensitizers as potential drugs. | <BR>One recent focus has been the discovery and development of calcium sensitizers as potential drugs. | ||
| − | <BR> The following figure captures many of the | + | <BR> The following figure captures many of the intrinsically disordered regions involved in the regulation of cardiac muscle contraction. |
<BR> [[Image:TnScheme.jpg|thumb|824x505px|left| ACS Chemical Biology 9 2121 (2014)]] | <BR> [[Image:TnScheme.jpg|thumb|824x505px|left| ACS Chemical Biology 9 2121 (2014)]] | ||
<BR> | <BR> | ||
Revision as of 09:39, 28 October 2014
Welcome to our lab in the
Department of Biochemistry
in the Faculty of Medicine at the
University of Alberta.
We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction.
Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research.
One recent focus has been the discovery and development of calcium sensitizers as potential drugs.
The following figure captures many of the intrinsically disordered regions involved in the regulation of cardiac muscle contraction.
The structure of a calcium sensitizing compound bound to the Troponin-C Troponin-I complex which regulates muscle contraction.
Links
| Publications | PubMed (Sykes BD) |
|---|---|
| Dept of Biochem | last 12 months |
| PDB | Protein Data Bank |
| NANUC | National NMR Centre |
| SpinSights | Agilent NMR |
Recent News
| *April/14 New group pic | *August/13 Updated group picture |
