Difference between revisions of "Sykes NMR Wiki"

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Welcome to our lab in the  
 
Welcome to our lab in the  
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[http://www.biochem.ualberta.ca/index.html Department of Biochemistry]
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[http://www.ualberta.ca/biochemistry/index.html Department of Biochemistry]
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in the  Faculty of Medicine at the 
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[http://www.ualberta.ca University of Alberta].  
 
[http://www.ualberta.ca University of Alberta].  
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<BR>We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of skeletal and cardiac muscle which regulate contraction. Nuclear magnetic resonance spectroscopy is a primary tool in our research.
 
 
<BR>
 
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<BR> [[Image:Dfbp-o.png]]
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<BR> [[Image:OC.jpeg|thumb|800x800px|center| Order of Canada]]
 
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<BR>
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The structure of a calcium sensitizing drug bound to the Troponin-C Troponin-I complex
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<BR>
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<BR> We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction.
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<BR> Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research.
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<BR> One recent focus has been the discovery and development of calcium sensitizers as potential drugs.
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<BR> The overlay of NMR solution structures and cryoEM structures reveal the mechanism of action of the drug W7.
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<BR>
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<BR> [[Image:W7.jpeg|thumb|800x800px|left| ACS Chemical Biology (2022)]]
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<BR>
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<BR> [[Image:TnScheme2.jpg|thumb|824x505px|left| ACS Chemical Biology 9 2121 (2014)]]
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<BR>
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<BR> [[Image:3mDPA.jpg]]
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<BR> Titration of drug into cardiac TnC-TnI chimera monitored using 1H,15- NMR correlation spectroscopy; JMCC 2016.
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<BR>
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<BR> [[Image:TOC_2018.png]]
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<BR>
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Mass spect data showing thioimidate formation in Troponin; Biochemistry, 2018.
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<BR>
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<BR>[[Image:Group_2018.png|thumb|824x505px|left|Group, 2018]]
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<BR>
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<BR>[[Image:Group 2020.JPG|thumb|824x505px|left|Present Group]]
  
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== ==
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<BR>
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<BR>[[Image:Golf2017.JPG|thumb|824x505px|left|Golf, 2017]]
  
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<BR>[[Image:Sykeslab-2011.jpg|thumb|824x505px|left|Brian Sykes' group, November 2011 (see [[Personnel]] and [[Pictures of the group]]) ]]
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<BR>[[Image:Exit.png|thumb|824x505px|left|Recent lab trip May 2018  ]]
  
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== Links ==
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<BR>[[Image:Winners_2018.JPG|thumb|824x505px|left|Winners, 2018]]
  
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{|border="5" | style="text-align: left;"
 
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! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Sykes%20BD%22&dispmax=50 Publications] || PubMed (Sykes BD)
 
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! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Bleackley%20RC%22OR%22Brindley%20DN%22OR%22Ellison%20MJ%22OR%22Fliegel%20L%22OR%22Glover%20JN%22OR%22Holmes%20CF%22OR%22James%20MN%22OR%22Lemire%20BD%22OR%22MacMillan%20AM%22OR%22McElhaney%20RN%22OR%22Michalak%20M%22OR%22Schultz%20MC%22OR%22Stone%20JC%22OR%22Sykes%20BD%22OR%22Vance%20DE%22OR%22Weiner%20JH%22OR%22Fernandez-Patron%20C%22OR%22Schang%20LM%22OR%22Spyracopoulos%20L%22OR%22Stuart%20DT%22OR%22Young%20HS%22OR%22Fahlman%20RP%22OR%22Goping%20IS%22OR%22Lemieux%20MJ%22OR%22Touret%20N%22AND%22last%2012%20months%22%5Bdp%5D&dispmax=50 Dept of Biochem] || last 12 months
 
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! [http://www.rcsb.org/ PDB] || Protein Data Bank
 
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! [http://www.nanuc.ca/ NANUC] || National NMR Centre
 
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! [http://pelican.rsvs.ulaval.ca/mediawiki/ WikiGagnéLagüe] || SMG and Lagüe's website
 
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! [http://www.varianinc.com/cgi-bin/nav?/products/nmr/ User Pages] || Agilent NMR
 
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== Recent News ==
 
  
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{|border="5" | style="text-align: left;"
 
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|*Nov 30/11 Updated group picture
 
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Latest revision as of 15:25, 12 December 2022

Welcome to our lab in the Department of Biochemistry University of Alberta.


Order of Canada




We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction.
Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research.
One recent focus has been the discovery and development of calcium sensitizers as potential drugs.
The overlay of NMR solution structures and cryoEM structures reveal the mechanism of action of the drug W7.


ACS Chemical Biology (2022)



ACS Chemical Biology 9 2121 (2014)




3mDPA.jpg

Titration of drug into cardiac TnC-TnI chimera monitored using 1H,15- NMR correlation spectroscopy; JMCC 2016.

TOC 2018.png
Mass spect data showing thioimidate formation in Troponin; Biochemistry, 2018.


Group, 2018



Present Group



Golf, 2017

Recent lab trip May 2018

Winners, 2018




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