|
|
| Line 17: |
Line 17: |
| | Mass spect data showing thioimidate formation in Troponin; Biochemistry, 2018. | | Mass spect data showing thioimidate formation in Troponin; Biochemistry, 2018. |
| | <BR> | | <BR> |
| − | <BR>[[Image:Group_2018.png|thumb|824x505px|left|Present group, 2018]] | + | <BR>[[Image:Group_2018.png|thumb|824x505px|left|Group, 2018]] |
| | + | <BR> |
| | + | <BR>[[Image:Group 2020.JPG|thumb|824x505px|left|Present Group]] |
| | | | |
| | <BR> | | <BR> |
| Line 27: |
Line 29: |
| | | | |
| | | | |
| − | {|border="5" | style="text-align: left;"
| |
| − | |-
| |
| − | ! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Sykes%20BD%22&dispmax=50 Publications] || PubMed (Sykes BD)
| |
| − | |-
| |
| − | ! [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=%22Bleackley%20RC%22OR%22Brindley%20DN%22OR%22Ellison%20MJ%22OR%22Fliegel%20L%22OR%22Glover%20JN%22OR%22Holmes%20CF%22OR%22James%20MN%22OR%22Lemire%20BD%22OR%22MacMillan%20AM%22OR%22McElhaney%20RN%22OR%22Michalak%20M%22OR%22Schultz%20MC%22OR%22Stone%20JC%22OR%22Sykes%20BD%22OR%22Vance%20DE%22OR%22Weiner%20JH%22OR%22Fernandez-Patron%20C%22OR%22Schang%20LM%22OR%22Spyracopoulos%20L%22OR%22Stuart%20DT%22OR%22Young%20HS%22OR%22Fahlman%20RP%22OR%22Goping%20IS%22OR%22Lemieux%20MJ%22OR%22Touret%20N%22OR%22Wille%20H%22OR%22Casey%20JR%22AND%22last%2012%20months%22%5Bdp%5D&dispmax=50 Dept of Biochem] || last 12 months
| |
| − | |-
| |
| − | ! [http://www.rcsb.org/ PDB] || Protein Data Bank
| |
| − | |-
| |
| − | ! [http://www.nanuc.ca/ NANUC] || National NMR Centre
| |
| − | |-
| |
| − | ! [https://agilent-ext.hosted.jivesoftware.com/login.jspa?logout/ SpinSights] || Agilent NMR
| |
| − | |-
| |
| − | ! [http://www.ehs.ualberta.ca/DocumentsandProcedures/~/media/Environmental%20Health%20and%20Safety/Documents/Biosafety/Biosafety_Guidelines.pdf Biosafety] || Biosafety Guidelines
| |
| − | |-
| |
| − | ! [http://www.ehs.ualberta.ca/DocumentsandProcedures/~/media/Environmental%20Health%20and%20Safety/Documents/Manuals%20and%20Documents/Lab_Chemical_Safety_Manual.ashx Chemsafety] || Chem Safety Manual
| |
| − | |-
| |
| − | |}
| |
| − | <BR>
| |
| − |
| |
| − | == Recent News ==
| |
| − |
| |
| − | {|border="5" | style="text-align: left;"
| |
| − | |-
| |
| − | |*Sept 2017 New edits
| |
| − |
| |
| − | |-
| |
| − | |}
| |
| | <BR> | | <BR> |
Revision as of 15:43, 28 January 2021
Welcome to our lab in the
Department of Biochemistry
University of Alberta.
We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction.
Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research.
One recent focus has been the discovery and development of calcium sensitizers as potential drugs.
The following figure captures many of the intrinsically disordered regions of the Troponin protein complex involved in the regulation of cardiac muscle contraction.
ACS Chemical Biology 9 2121 (2014)
Titration of drug into cardiac TnC-TnI chimera monitored using 1H,15- NMR correlation spectroscopy; JMCC 2016.
Mass spect data showing thioimidate formation in Troponin; Biochemistry, 2018.
