Difference between revisions of "Sykes NMR Wiki"
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Welcome to our lab in the | Welcome to our lab in the | ||
− | [http://www.ualberta.ca/ | + | [http://www.ualberta.ca/biochemistry/index.html Department of Biochemistry] |
[http://www.ualberta.ca University of Alberta]. | [http://www.ualberta.ca University of Alberta]. | ||
<BR>We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction. | <BR>We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction. |
Revision as of 14:55, 29 October 2020
Welcome to our lab in the
Department of Biochemistry
University of Alberta.
We study of the structure, dynamics and function of proteins, especially those that make up the thin filament of cardiac muscle and regulate contraction.
Structural biology, using nuclear magnetic resonance spectroscopy, is the primary tool in our research.
One recent focus has been the discovery and development of calcium sensitizers as potential drugs.
The following figure captures many of the intrinsically disordered regions of the Troponin protein complex involved in the regulation of cardiac muscle contraction.
Titration of drug into cardiac TnC-TnI chimera monitored using 1H,15- NMR correlation spectroscopy; JMCC 2016.
Mass spect data showing thioimidate formation in Troponin; Biochemistry, 2018.
Publications | PubMed (Sykes BD) |
---|---|
Dept of Biochem | last 12 months |
PDB | Protein Data Bank |
NANUC | National NMR Centre |
SpinSights | Agilent NMR |
Biosafety | Biosafety Guidelines |
Chemsafety | Chem Safety Manual |
Recent News
*Sept 2017 New edits |